Add all sauce ingredients to a medium bowl and mix until well incorporated. Set aside.
In a large bowl add chopped onion, minced garlic, Italian seasonings, salt, bread crumbs, ketchup, and milk to 2 pounds of ground beef. Mix well.
Put mixture into loaf pan and bake 20 minutes at 400 degrees. Remove from the oven and add the meatloaf sauce. Place back into the oven for another 20 minutes, or until the internal temperature of the meat registers at 160 degrees.
Remove from oven and allow meatloaf to rest for 10 minutes before slicing and eating.
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